pancreatic cancer clinical trials

The participant will be asked to complete a survey about their health and family history of cancer and to give a blood sample for specific gene testing and storage for future research studies. The overall purpose of this study is to understand the factors that increase susceptibility and expression of pancreatic cancer and melanoma in high risk families. Patients with metastatic cancer and weight loss sometimes are not able to receive treatment due to physical weakness or debility. Clinical trials are research studies that evaluate the safety and effectiveness of new treatment approaches for diseases. The purpose of these phase I/II trial studies is to analyze the side effects and best dose of liposomal irinotecan and rucaparib when given together with fluorouracil and leucovorin calcium, and to see how well they work in treating patients with pancreatic, colorectal, gastroesophageal, or biliary cancer that has spread to other places in the body. 76 in progress, 44 open to eligible people . Restaging and imaging studies will be performed to assess disease relapse per NCCN guidelines. Subjects will be assessed according to standard of care. In some cases, a study may give you access to new therapies that are not yet widely available. The purpose of this study is to develop a data-driven approach that enables healthcare providers to “prescribe” exercise in the appropriate dose in a manner analogous to prescribing a drug. The study will enroll up to 50 patients in the US and Europe. Radiation therapy uses high-energy x-rays to kill tumor cells. COVID-19 update: The current coronavirus outbreak has affected what research can be carried out and when. open to eligible people ages 18 years and up . The purpose of this study is to assess the best 2-year overall survival when comparing fluorouracil, irinotecan hydrochloride, and oxaliplatin (combination chemotherapy) to gemcitabine hydrochloride and nab-paclitaxel, given before surgery for treating patients who have pancreatic cancer that can be removed by surgery. Palliative care focuses on improving the quality of life for patients with advanced diseases and their family members by providing support for relief of physical symptoms, emotional and psychological support, and counseling. A Multi-center Trial to Evaluate Multiple Regimens in Metastatic Pancreatic Cancer. The Pancreatic Cancer Action Network strongly recommends clinical trials at diagnosis and during every treatment decision. The purpose of this study is to assess DNA markers in pancreatic juice and stool for the detection of pancreatic cancer and precancer. A single copy of these materials may be reprinted for noncommercial personal use only. The study is currently in phase III. You should always discuss the pros and cons of participating in a clinical trial with your doctor. In partnership with Berg Health, LLC, biomarkers will be investigated for potential use in early detection of pancreatic cancer, to determine prognosis of patients, and to find the most appropriate treatments for patients. This study will evaluate the safety profile, tolerability, PK, PD, and preliminary efficacy of BMS-813160 in combination with either chemotherapy or nivolumab in participants with metastatic colorectal and pancreatic cancers. Search for closest city to find more detailed information on a research … Giving binimetinib and encorafenib may work better compared to the usual treatment in treating patients with pancreatic cancer and a somatic BRAF V600E mutation. Learn how surgeons and oncologists at the Medical College of Wisconsin have developed a unique personalized medicine clinical trial for pancreatic cancer. The purpose of this study is to evaluate the safety and clinical activity of the combination of durvalumab with CV301 in combination with maintenance chemotherapy for patients with metastatic colorectal or pancreatic cancer whose disease is stable on, or responding to 1st line therapy for metastatic disease. You may be offered the opportunity to take part in a clinical trial at some point during your treatment with us. Therefore, these robust preclinical findings will be tested in the proposed phase I trial. Clinical Trials for Pancreatic Cancer Clinical trials are medical research studies where an intervention or treatment is offered to people to test how well it works compared to the current standard. We wish to examine pancreatic adenocarcinoma cell lines to determine what genes are being expressed in the cells that might cause muscle wasting in patients. The purpose of this study is to determine the maximum dose of LDE225 and BKM120 that can be safely given together to patients and/or the dose that will be used in future studies. This randomized phase II trial studies how well standard systemic chemotherapy followed by intensified radiochemotherapy or standard radiochemotherapy preceded by intensified systemic chemotherapy works compared to standard systemic chemotherapy followed by standard radiochemotherapy in treating patients with pancreatic cancer that cannot be removed by surgery. In addition, somatic mutations in Homologous Recombination Repair (HRR) genes can confer sensitivity as well, and have been reported to double the number of patients potentially eligible for such therapy. A listing of Pancreatic Cancer medical research trials actively recruiting patient volunteers. The primary purpose of this study is to obtain de-identified, clinically characterized, whole blood specimens to evaluate biomarkers associated with cancer for diagnostic assay development. Both arms will continue treatment until disease progression or unacceptable toxicity. (A liquid biopsy analyzes free-floating DNA in a blood sample. Cystic tumors of the pancreas are fluid-filled growths. Cancer vaccines: Several types of vaccines for boosting the body’s immune response to pancreatic cancer cells are being tested in clinical trials. All patients will receive standard of care treatment for their pancreatic cancer. RECIST will be used to validate the findings in cases of relapse. All … This partially randomized phase I trial studies the side effects and best dose of disulfiram when given together with gemcitabine hydrochloride in treating patients with a solid tumor that cannot be removed by surgery (unresectable) or pancreatic cancer that has spread to other places in the body (metastatic) and to compare whether disulfiram and gemcitabine hydrochloride may reduce tumor induced muscle loss. The research will be conducted at Baylor College of Medicine (BCM) and Baylor St. Luke's Medical Center (BSLMC). This clinical study is in subjects who are 18 years old or older with locally advanced pancreatic cancer who have not received prior treatment for their pancreatic cancer. All Female Male . Find a clinical trial Search by cancer type, drug name, trial name, or choose from a list of cancer types. Every treatment available today was approved through a clinical trial. This phase II trial studies how well sapanisertib works in treating patients with pancreatic neuroendocrine tumor that has spread to other places in the body, does not respond to treatment, or cannot be surgically removed. A Phase 1b/2 randomized, open-label trial to evaluate the safety, tolerability, PK, and preliminary antitumor activity of immunotherapy-based treatment combinations in participants with metastatic pancreatic ductal adenocarcinoma. The purpose of this study is to determine the feasibility of performing HIVM in patients with deep space solid tumors during standard course of surgical resection. The purpose of this study is to determine if TH-302 combined with Gemcitabine versus Gemcitabine alone is as safe and effective in the treatment of patients who have first-line metastatic pancreatic adenocarcinoma. The objective of this study is to estimate the R0 resection rate in patients with Resectable Pancreatic Ductal Adenocarcinoma (R-PDAC) as well as those with Resectable Pancreatic Ductal Adenocarcinoma (BR-PDAC) independently in response to neoadjuvant sequential therapy of combination nab-paclitaxel and gemcitabine followed by stereotactic body radiotherapy (SBRT). The key purpose of the main part of the study is to assess efficacy and safety of anetumab ravtansine as monotherapy or combination therapy for mesothelin expressing advanced solid tumors. Number of listed Pancreatic Cancer Trials: 165 (as of 2020) Benefits of clinical trials Clinical trials contribute to knowledge and progress towards treating cancer. This is a Phase 2 multicenter, open-label, non-randomized study to examine the safety and effectiveness of BPM31510 administered as a 144-hour continuous intravenous (IV) infusion as a monotherapy or in combination with gemcitabine in advanced pancreatic cancer patients as 2nd / 3rd line therapy. Find out about UK research looking at pancreatic cancer, including new tests and treatment. The purpose of this study is to assess the effectiveness, safety, biological activity, and drug/body interactions of ACP-196 alone and combined with Pembrolizumab for the treatment of patients who have advanced or metastatic pancreatic cancer. - Staging by pancreatic protocol, helical abdominal computed tomography (with contrast) or MRI (with contrast) required (endoscopic ultrasound is not required). Clinical trials are research studies that are done to investigate new treatments through the observation of patients. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab may also stop the growth of cancer by blocking blood flow to the tumor. The purpose of this study is to determine whether an investigational immuno-therapy, cabiralizumab in combination with nivolumab, with or without chemotherapy, is effective for the treatment of advanced pancreatic cancer. The purpose of this study is to develop a test for detection of pancreatic cancer by looking at the subject's DNA. A study cycle will consist of daily and continuous oral administration of BBI608 for four weeks (28 days) in combination with FOLFOX6 with and without bevacizumab, or CAPOX or FOLFIRI with and without bevacizumab, or regorafenib. A Multi-center Trial to Evaluate Multiple Regimens in Metastatic Pancreatic Cancer open to eligible people ages 18 years and up Precision Promise is a multi-center, seamless Phase 2/3 platform trial designed to evaluate multiple regimens in metastatic pancreatic cancer. This is a frequent problem that is most commonly due to type 2 diabetes. Subjects will be enrolled into one of six treatment arms. Drugs used in chemotherapy, such as liposomal irinotecan, fluorouracil, leucovorin calcium, and rucaparib, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Although unselected trials in pancreatic cancer with immunotherapy alone have yet to be successful, we hypothesize that ... Test the safety, immune response and efficacy of GVAX pancreas vaccine (with cyclophosphamide) and CRS-207 compared to chemotherapy or CRS-207 alone in adults with previously treated metastatic pancreatic adenocarcinoma. At Memorial Sloan Kettering, our mission has always been a singular one: to care for and cure people with cancer. Clinical trials for pancreatic cancer may include: finding ways to diagnose pancreatic cancer at an earlier stage finding better ways of giving existing treatments – for example, combining different chemotherapy drugs or giving combinations in different ways The goal of this study is to establish and maintain a biospecimen bank containing samples of neoplasms, cysts, normal tissue, blood and/or any other tissue or cystic fluid from patients undergoing a diagnostic or therapeutic procedure for pancreatic disease. Blood and FDG PET-MRI/MRCP based biomarkers for assessment of response to cancer.! 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